Keiko Yamakawa Selected Research

4- (N- methyl- N- nitrosamino)- 1- (3- pyridyl)- 1- butanone

12/2014	Significance of the progesterone receptor and epidermal growth factor receptor, but not the estrogen receptor, in chemically induced lung carcinogenesis in female A/J mice.
12/2013	Gender-dependent effects of gonadectomy on lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female and male A/J mice.
1/2012	Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway.
1/2011	Lack of promoting effects from physical pulmonary collapse in a female A/J mouse lung tumor initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) with remarkable mesothelial cell reactions in the thoracic cavity by the polymer.
1/2010	Molecular analysis of carcinogen-induced rodent lung tumors: Involvement of microRNA expression and Krαs or Egfr mutations.
9/2009	Lack of Modifying Effects of Intratracheal Instillation of Quartz or Dextran Sulfate Sodium (DSS) in Drinking Water on Lung Tumor Development Initiated with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Female A/J Mice.
7/2009	8-Methoxypsoralen, a potent human CYP2A6 inhibitor, inhibits lung adenocarcinoma development induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in female A/J mice.
10/2008	Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J female mice.
9/2008	Establishment of a bioassay model for lung cancer chemoprevention initiated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female A/J mice.
3/2006	Dose dependent inhibitory effects of dietary 8-methoxypsoralen on NNK-induced lung tumorigenesis in female A/J mice.

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Keiko Yamakawa Research Topics

Disease

21	Neoplasms (Cancer) 01/2022 - 01/2005
21	Carcinogenesis 06/2021 - 05/2005
12	Adenocarcinoma 12/2021 - 05/2005
12	Adenoma (Adenomas) 01/2020 - 10/2007
7	Inflammation (Inflammations) 06/2021 - 09/2009
7	Hyperplasia 10/2018 - 09/2008
6	Lung Neoplasms (Lung Cancer) 01/2022 - 07/2007
4	Pancreatic Neoplasms (Pancreatic Cancer) 01/2022 - 08/2019
4	Body Weight (Weight, Body) 01/2020 - 03/2006
3	Carcinoma (Carcinomatosis) 01/2021 - 10/2007
3	Pneumonia (Pneumonitis) 10/2018 - 03/2014
3	Adenocarcinoma of Lung 03/2014 - 07/2009
2	Fibrosis (Cirrhosis) 01/2020 - 12/2012
2	Colonic Neoplasms (Colon Cancer) 12/2012 - 12/2011
1	Kidney Neoplasms (Kidney Cancer) 01/2022
1	Adenosquamous Carcinoma 01/2022
1	Pancreatoblastoma 01/2021
1	Granuloma 01/2020
1	Silicosis 01/2020
1	Hypertrophy 01/2020
1	Type 2 Diabetes Mellitus (MODY) 01/2020
1	Diabetes Mellitus 01/2020
1	Genomic Instability 07/2018
1	Pulmonary Edema 04/2017
1	Neurologic Manifestations (Neurological Manifestations) 12/2012
1	Reinjuries 12/2012
1	Neoplasm Metastasis (Metastasis) 12/2012
1	Lymphadenopathy 12/2012
1	Edema (Dropsy) 12/2012
1	Rectal Neoplasms (Rectal Cancer) 01/2012
1	Hemorrhage 12/2011

Drug/Important Bio-Agent (IBA)

10	4- (N- methyl- N- nitrosamino)- 1- (3- pyridyl)- 1- butanoneIBA 12/2014 - 03/2006
8	QuartzIBA 01/2020 - 09/2009
7	diisopropanolnitrosamineIBA 10/2018 - 01/2010
5	CarcinogensIBA 06/2021 - 01/2010
5	NitrosaminesIBA 07/2018 - 07/2007
4	QuinoxalinesIBA 03/2010 - 09/2009
4	Methoxsalen (Oxsoralen)FDA Link 07/2009 - 03/2006
3	ParaffinIBA 01/2022 - 03/2014
3	Formaldehyde (Formol)FDA Link 01/2022 - 03/2014
3	Proteins (Proteins, Gene)FDA Link 01/2016 - 10/2007
3	Messenger RNA (mRNA)IBA 10/2007 - 03/2006
2	Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)IBA 10/2018 - 10/2014
2	Ambroxol (Mucosolvan)IBA 10/2018 - 04/2017
2	ErbB Receptors (EGF Receptor)IBA 12/2014 - 01/2010
2	Drinking WaterIBA 10/2014 - 09/2009
2	SmokeIBA 12/2012 - 10/2007
2	Bevacizumab (Avastin)FDA Link 12/2012 - 01/2012
2	Nicotine FDA Link 12/2012 - 01/2012
2	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2012 - 07/2009
2	EnzymesIBA 07/2007 - 03/2006
2	Tumor Viral Antigens (Large T Antigen)IBA 06/2005 - 05/2005
2	probasinIBA 06/2005 - 05/2005
1	Threonine (L-Threonine)FDA Link 01/2022
1	alpha-Fetoproteins (alpha-Fetoprotein)IBA 01/2022
1	Monoclonal AntibodiesIBA 01/2022
1	Indicators and Reagents (Reagents)IBA 01/2022
1	RNA-Dependent RNA Polymerase (RNA Dependent RNA Polymerase)IBA 01/2022
1	Tumor Biomarkers (Tumor Markers)IBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 01/2022
1	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2022
1	Carcinoembryonic AntigenIBA 12/2021
1	CateninsIBA 01/2021
1	Cyclin D1IBA 01/2021
1	Urea (Carbamide)FDA LinkGeneric 01/2020
1	Silicon Dioxide (Silica)FDA LinkGeneric 01/2020
1	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2020
1	NitrogenIBA 01/2020
1	BilirubinIBA 01/2020
1	CreatinineIBA 01/2020
1	Nucleic AcidsIBA 08/2019
1	Pulmonary Surfactants (Pulmonary Surfactant)IBA 10/2018
1	DNA (Deoxyribonucleic Acid)IBA 07/2018
1	Pharmaceutical PreparationsIBA 04/2017
1	Expectorants (Mucolytics)IBA 04/2017
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2016
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2016
1	MitogensIBA 01/2016
1	Codon (Codons)IBA 01/2016
1	Mitogen-Activated Protein Kinase 3IBA 01/2016
1	Estrogen ReceptorsIBA 12/2014
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 12/2014
1	Hormones (Hormone)IBA 12/2014
1	Progesterone Receptors (Progesterone Receptor)IBA 12/2014
1	Interleukin-6 (Interleukin 6)IBA 10/2014
1	Gonadal Steroid Hormones (Sex Hormones)IBA 12/2013
1	XELOXIBA 12/2012
1	CaspasesIBA 01/2012
1	CotinineIBA 01/2012
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2012

Therapy/Procedure

3	Therapeutics 01/2022 - 08/2019
2	Neoadjuvant Therapy 12/2021 - 01/2021
2	Drug Therapy (Chemotherapy) 12/2012 - 01/2012
1	Precision Medicine 08/2019
1	Castration 12/2013
1	Ovariectomy (Oophorectomy) 12/2013
1	Colostomy 01/2012
1	Aftercare (After-Treatment) 01/2012
1	Length of Stay 12/2011
1	Colectomy 12/2011